Spring honey from Apis laboriosa hives in the Lamjung area contains grayanotoxin I and III, compounds derived from the nectar of Rhododendron luteum and related species that bloom at 1,500 to 3,000 m in March and April. Grayanotoxin binds to sodium channels in nerve and muscle cells, causing a dose-dependent response: at small doses (a teaspoon or less), a brief warmth and mild dizziness; at larger doses, nausea, low blood pressure, bradycardia and, in rare cases, disorientation lasting up to 24 hours.
The spring harvest honey from Bhujung and the surrounding villages has been traded across Central and East Asia for over two centuries as a medicine for hypertension and diabetes, and in smaller quantities as a recreational substance. International buyers, primarily in Japan, South Korea and Germany, now pay USD 60 to USD 80 per kilogram for authenticated Nepali mad honey compared to USD 5 to USD 10 for ordinary honey. The hunters and village cooperatives retain most of this margin. On this trip, tastings of spring honey are offered in small, guide-supervised quantities at the harvest site; it is not safe to eat freely and children should not taste it.